Oct 13, 2023
Humans cannot synthesize L-ascorbic acid (vitamin C). As a result, L-ascorbic acid must be obtained from dietary sources. L-ascorbic acid is an electron donor in the organism and is an important part of human nutrition as an antioxidant. In its deficiency, a wide variety of chronic complex diseases, especially scurvy, can occur. These results arise from the functions of L-ascorbic acid in the synthesis of collagen and hormones, apart from antioxidant mechanisms (Timpson NJ. et al., 2010). Since it is not stored in the body, it should be consumed in a balanced way in your daily nutrition routine. The richest sources of vitamin C include red capsicum, green pepper, fresh seasonal vegetables and fruits.
Vitamin C and SLC23A1 Gene Relationship
Transport of ascorbate into the cell is achieved by sodium L-ascorbic acid (“vitamin C”) cotransporters (SVCTs), and SVCT has two isoforms encoded by the SLC23A2 and SLC23A1 genes, respectively (Timpson NJ. et al., 2010).
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The table above contains the gene (SLC23A1) and its polymorphism (rs33972313) involved in vitamin C metabolism. This variant is located within the SLC23A1 gene, which encodes the active L-ascorbic acid transporter SVCT1. In the presence of the A allele, it is associated with low levels of circulating L-ascorbic acid (Timpson NJ. et al., 2010; E. J. et al., 2013).
REFERENCES
Duell, E. J., Lujan-Barroso, L., Llivina, C., Muñoz, X., Jenab, M., Boutron-Ruault, M. C., Clavel-Chapelon, F., Racine, A., Boeing, H., Buijsse, B., Canzian, F., Johnson, T., Dalgård, C., Overvad, K., Tjønneland, A., Olsen, A., Sánchez, S. C., Sánchez-Cantalejo, E., Huerta, J. M., Ardanaz, E., … González, C. A. (2013). Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort. Genes & nutrition, 8(6), 549–560. https://doi.org/10.1007/s12263-013-0346-6
Timpson, N. J., Forouhi, N. G., Brion, M. J., Harbord, R. M., Cook, D. G., Johnson, P., McConnachie, A., Morris, R. W., Rodriguez, S., Luan, J., Ebrahim, S., Padmanabhan, S., Watt, G., Bruckdorfer, K. R., Wareham, N. J., Whincup, P. H., Chanock, S., Sattar, N., Lawlor, D. A., & Davey Smith, G. (2010). Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. The American journal of clinical nutrition, 92(2), 375–382. https://doi.org/10.3945/ajcn.2010.29438